Phenotypes Associated with This Genotype

Genotype
MGI:2679902

• Allelic Composition: Pten^tm2.1Ppp/Pten^tm2.1Ppp; Tg(Pbsn-cre)8113ANg/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:86212 )

♂ • complete penetrance of invasive and diffuse prostate cancer

♂ • disruption of basement membrane and organ infiltration

♂ • tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe

endocrine/exocrine glands

abnormal prostate gland morphology ( J:86212 )

♂ • irregular cells

prostate gland epithelial hyperplasia ( J:86212 )

♂ • focal areas of epithelial hyperplasia

♂ • increased proliferation of epithelial cells

enlarged prostate gland ( J:86212 )

♂ • enlargement of prostate, less pronounced than in homozygotes carrying Tg(Pbsn-cre)4Prb

increased prostate gland tumor incidence ( J:86212 )

♂ • complete penetrance of invasive and diffuse prostate cancer

♂ • disruption of basement membrane and organ infiltration

♂ • tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe

reproductive system

abnormal prostate gland morphology ( J:86212 )

♂ • irregular cells

prostate gland epithelial hyperplasia ( J:86212 )

♂ • focal areas of epithelial hyperplasia

♂ • increased proliferation of epithelial cells

enlarged prostate gland ( J:86212 )

♂ • enlargement of prostate, less pronounced than in homozygotes carrying Tg(Pbsn-cre)4Prb

increased prostate gland tumor incidence ( J:86212 )

♂ • complete penetrance of invasive and diffuse prostate cancer

♂ • disruption of basement membrane and organ infiltration

♂ • tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe