Analysis Tools
reproductive system
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• large, irregular cells, occasionally forming cryptic glandular structures
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• prostate epithelial dysplasia
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• focal areas of epithelial hyperplasia
(J:86212)
• increased proliferation of epithelial cells
(J:86212)
• mutant prostates contain a 20-fold increase in senescent epithelial cells compared to wild-type prostates
(J:100683)
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• massive enlargement of all prostatic lobes evident at 2 to 3 months of age, complete penetrance
|
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• tumors were undifferentiated and often affected multiple lobes, suggesting multifocal origns
(J:86212)
• complete penetrance of invasive and diffuse prostate cancer with disruption of basement membrane and signs of organ infiltration
(J:86212)
• invasive prostatic cancer develops after a 4-6 month latency; however none of the mutants had died of prostatic cancer by 10 months of age
(J:100683)
• tumors retain clearly defined urogenital organ boundaries
(J:100683)
|
|
|
(J:100683)
(J:163589)
|
increased prostate intraepithelial neoplasia incidence
(
J:100683
, J:163589
, J:200002
, J:239660
)
|
|
• high-grade prostatic intraepithelial neoplasia are seen in all 3 prostatic lobes in 9-week old mutants
(J:100683)
(J:163589)
• that does not progress to grossly invasive disease
(J:200002)
• mice develop diffuse, highly proliferative high-grade prostatic intraepithelial neoplasia without invasive cancer but with cystic enlargement of the anterior prostate
(J:239660)
|
neoplasm
|
|
• tumors were undifferentiated and often affected multiple lobes, suggesting multifocal origns
(J:86212)
• complete penetrance of invasive and diffuse prostate cancer with disruption of basement membrane and signs of organ infiltration
(J:86212)
• invasive prostatic cancer develops after a 4-6 month latency; however none of the mutants had died of prostatic cancer by 10 months of age
(J:100683)
• tumors retain clearly defined urogenital organ boundaries
(J:100683)
|
|
|
(J:100683)
(J:163589)
|
increased prostate intraepithelial neoplasia incidence
(
J:100683
, J:163589
, J:200002
, J:239660
)
|
|
• high-grade prostatic intraepithelial neoplasia are seen in all 3 prostatic lobes in 9-week old mutants
(J:100683)
(J:163589)
• that does not progress to grossly invasive disease
(J:200002)
• mice develop diffuse, highly proliferative high-grade prostatic intraepithelial neoplasia without invasive cancer but with cystic enlargement of the anterior prostate
(J:239660)
|
endocrine/exocrine glands
|
|
• large, irregular cells, occasionally forming cryptic glandular structures
|
|
|
• prostate epithelial dysplasia
|
|
|
• focal areas of epithelial hyperplasia
(J:86212)
• increased proliferation of epithelial cells
(J:86212)
• mutant prostates contain a 20-fold increase in senescent epithelial cells compared to wild-type prostates
(J:100683)
|
|
|
• massive enlargement of all prostatic lobes evident at 2 to 3 months of age, complete penetrance
|
|
|
• tumors were undifferentiated and often affected multiple lobes, suggesting multifocal origns
(J:86212)
• complete penetrance of invasive and diffuse prostate cancer with disruption of basement membrane and signs of organ infiltration
(J:86212)
• invasive prostatic cancer develops after a 4-6 month latency; however none of the mutants had died of prostatic cancer by 10 months of age
(J:100683)
• tumors retain clearly defined urogenital organ boundaries
(J:100683)
|
|
|
(J:100683)
(J:163589)
|
increased prostate intraepithelial neoplasia incidence
(
J:100683
, J:163589
, J:200002
, J:239660
)
|
|
• high-grade prostatic intraepithelial neoplasia are seen in all 3 prostatic lobes in 9-week old mutants
(J:100683)
(J:163589)
• that does not progress to grossly invasive disease
(J:200002)
• mice develop diffuse, highly proliferative high-grade prostatic intraepithelial neoplasia without invasive cancer but with cystic enlargement of the anterior prostate
(J:239660)
|
