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Phenotypes Associated with This Genotype
Genotype
MGI:2679599
Allelic
Composition		 Grb2tm1Paw/Grb2+
Tg(MMTV-PyVT)634Mul/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:51424 )
• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

integument
increased mammary adenocarcinoma incidence ( J:51424 )
• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:51424 )
• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory