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Phenotypes Associated with This Genotype
Genotype
MGI:2678469
Allelic
Composition		 Hprt1b-m3/Y
Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1b-m3 mutation (4 available); any Hprt1 mutation (1280 available)
Impdh1tm1Bmi mutation (0 available); any Impdh1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28
decreased splenocyte proliferation ( J:85443 )
• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin
abnormal lymphopoiesis ( J:85443 )
• light but significant drop in proportion of T cells
• fewer cells in S phase
decreased cytotoxic T cell cytolysis ( J:85443 )
• deficient T cell cytolytic effect

immune system
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28
decreased splenocyte proliferation ( J:85443 )
• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin
abnormal lymphopoiesis ( J:85443 )
• light but significant drop in proportion of T cells
• fewer cells in S phase
decreased cytotoxic T cell cytolysis ( J:85443 )
• deficient T cell cytolytic effect
decreased interleukin-4 secretion ( J:85443 )
• decreased secretion of Il-4 due to decreased GTP levels
• Il-2 levels remain more or less normal

cellular
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28
decreased splenocyte proliferation ( J:85443 )
• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory