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Phenotypes Associated with This Genotype
Genotype
MGI:2678248
Allelic
Composition
Prkntm1Roo/Prkntm1Roo
Genetic
Background
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Roo mutation (0 available); any Prkn mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• reduced amphetamine-induced motor activity

growth/size/body
• reduced body weight after weaning, both males and females

homeostasis/metabolism
• reduced rectal temperature relative to wild-type
• increased in the limbic brain areas
• increased levels of the MAO-derived metabolite, DOPAC, relative to COMT-derived metabolite, 3-MT, indicating an impairment of dopamine release

muscle
N
• no evidence of muscle degeneration

nervous system
N
• brain morphology, weight, and size were normal
• inhibition of dopamine neurotransmission
• inhibition of glutamate neurotransmission
• normal levels of 5-HT and 5-HIAA in the striatum, limbic system, diencephalon, and brainstem

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
J:85561


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory