Phenotypes Associated with This Genotype

Genotype
MGI:2675747

• Allelic Composition: Hhip^tm1Amc/Hhip^tm1Amc; Ptch1^tm1Mps/Ptch1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:85472 )

• accelerated lethality before E13

growth/size/body

increased embryo size ( J:94269 )

• about 56% of embryos

respiratory system

small lung ( J:85472 )

• much smaller lungs

abnormal pulmonary alveolar duct morphology ( J:94269 )

• branching pattern defect much more severe

nervous system

abnormal neural tube morphology ( J:94269 )

• enlarged neural tube

• ventricular zone grossly normal

incomplete rostral neuropore closure ( J:94269 )

• normal sized embryos with "open brains"

• moderate overgrowth in some cases

increased neuronal precursor cell number ( J:94269 )

• general expansion of neuronal precursor populations

digestive/alimentary system

abnormal stomach glandular epithelium morphology ( J:85472 )

• very reduced in thickness

endocrine/exocrine glands

abnormal pancreas development ( J:85472 )

• at E12.5, pancreas morphogenesis and cell differentiation are severely impaired

abnormal branching involved in pancreas development ( J:85472 )

• impaired branching of pancreatic epithelium into surrounding mesenchyme

• pancreatic epithelium significantly reduced

embryo

increased embryo size ( J:94269 )

• about 56% of embryos

abnormal neural tube morphology ( J:94269 )

• enlarged neural tube

• ventricular zone grossly normal

incomplete rostral neuropore closure ( J:94269 )

• normal sized embryos with "open brains"

• moderate overgrowth in some cases