Mouse Genome Informatics
hm
    Akt1tm1Mbb/Akt1tm1Mbb
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• normal numbers of homozygous embryos at E13.5
• by 2-3 weeks after birth, fewer than expected numbers of homozygotes seen
• significant numbers of deaths among homozygotes observed with first three days of life
• survivors were fertile

nervous system
• in mice treated with amphetamine
• however, mice exhibit normal prepulse inhibition at baseline or following treatment with MK801

growth/size/body
• 20% reduction in body weight at birth
• at 14 months, homozygous males were only about 75% normal weight

behavior/neurological
N
• mice exhibit normal startle response (J:185487)

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:185487