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Phenotypes Associated with This Genotype
Genotype
MGI:2674288
Allelic
Composition
Akt1tm1Mbb/Akt1tm1Mbb
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Mbb mutation (1 available); any Akt1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• normal numbers of homozygous embryos at E13.5 (J:72176)
• by 2-3 weeks after birth, fewer than expected numbers of homozygotes seen (J:72176)
• significant numbers of deaths among homozygotes observed with first three days of life (J:72176)
• survivors were fertile (J:72176)
• normal numbers of homozygous embryos at E13.5 (J:72176)
• by 2-3 weeks after birth, fewer than expected numbers of homozygotes seen (J:72176)
• significant numbers of deaths among homozygotes observed with first three days of life (J:72176)
• survivors were fertile (J:72176)

nervous system
• in mice treated with amphetamine (J:185487)
• however, mice exhibit normal prepulse inhibition at baseline or following treatment with MK801 (J:185487)
• in mice treated with amphetamine (J:185487)
• however, mice exhibit normal prepulse inhibition at baseline or following treatment with MK801 (J:185487)

growth/size/body
• 20% reduction in body weight at birth (J:72176)
• at 14 months, homozygous males were only about 75% normal weight (J:72176)
• 20% reduction in body weight at birth (J:72176)
• at 14 months, homozygous males were only about 75% normal weight (J:72176)

behavior/neurological
N
• mice exhibit normal startle response (J:185487)
• mice exhibit normal startle response (J:185487)

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:185487


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory