Phenotypes Associated with This Genotype

Genotype
MGI:2674277

• Allelic Composition: Nck1^tm1Paw/Nck1^tm1Paw; Nck2^tm1Paw/Nck2^tm1Paw
• Genetic Background: involves: 129/Ola * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83956 )

• no double homozygous mutant mice born

• double homozygotes present at Mendelian ratios at E8.5

• by E10.5 double homozygotes reduced to one third of expected

• no double homozygous mutant embryos by E12.5

cellular

abnormal cell physiology ( J:83956 )

• actin fiber abnormalities

• decreased fibroblast mobility

embryo

abnormal developmental patterning ( J:83956 )

• deficient axial rotation

abnormal embryonic tissue morphology ( J:83956 )

abnormal neural tube morphology ( J:83956 )

incomplete rostral neuropore closure ( J:83956 )

• neural tube closure to level of otic vesicles but no further anteriorly

wavy neural tube ( J:83956 )

notochord degeneration ( J:83956 )

• initial development is normal at the 2 to 4 somite stage

• degenerates rapidly after initial formation

abnormal extraembryonic tissue morphology ( J:83956 )

abnormal allantois morphology ( J:83956 )

• growing toward headfold structures

dilated allantois ( J:83956 )

• allantois misshapen and balloon like

failure of chorioallantoic fusion ( J:83956 )

• lack of chorioallantoic fusion

• due to misshapen allantois

• failure to develop definitive embryonic circulation

nervous system

abnormal neural tube morphology ( J:83956 )

incomplete rostral neuropore closure ( J:83956 )

• neural tube closure to level of otic vesicles but no further anteriorly

wavy neural tube ( J:83956 )