Phenotypes Associated with This Genotype

Genotype
MGI:2674125

• Allelic Composition: Rttn^{Gt(pGT1.8geo)7Pgr}/Rttn^{Gt(pGT1.8geo)7Pgr}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:76233 )

• homozygous embryos die at E9.5-E11.5

cardiovascular system

abnormal direction of heart looping ( J:76233 )

• homozygotes exhibit randomized heart looping

pericardial effusion ( J:76233 )

• a ballooning of the pericardial sac and blood accumulations were found at various stages

embryo

abnormal embryo turning ( J:76233 )

• axial rotation was not completed or in some cases was not initiated

failure of initiation of embryo turning ( J:76233 )

decreased embryo size ( J:76233 )

• at E9.5, homozygous embryos are 50% smaller than littermates and remain smaller until death

abnormal neural tube morphology ( J:76233 )

notochord degeneration ( J:76233 )

• cells of the notochord appear separated, do not form a compact structure and exhibit signs of apoptosis

abnormal somite development ( J:76233 )

• at E9.5, only 10-12 somite pairs have formed; these degenerate and by E10.5 no recognizable somites remain

growth/size/body

decreased embryo size ( J:76233 )

• at E9.5, homozygous embryos are 50% smaller than littermates and remain smaller until death

nervous system

abnormal neural tube morphology ( J:76233 )

homeostasis/metabolism

pericardial effusion ( J:76233 )

• a ballooning of the pericardial sac and blood accumulations were found at various stages