Phenotypes Associated with This Genotype

Genotype
MGI:2674120

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:67966 )

• no mutant mice are born

craniofacial

absent craniofacial bones ( J:67966 )

• craniofacial bones derived from neural crest cells are absent

• bones present include optic vesicle, basioccipital, exoccipital

skeleton

absent craniofacial bones ( J:67966 )

• craniofacial bones derived from neural crest cells are absent

• bones present include optic vesicle, basioccipital, exoccipital

nervous system

abnormal neural tube morphology ( J:67966 )

• shortened neural tube

abnormal brain morphology ( J:67966 )

abnormal brain development ( J:67966 )

• brain morphogenesis grossly abnormal between E10.5 and 18.5

absent midbrain-hindbrain boundary ( J:67966 )

• isthmic border between midbrain and rhombencephalon not visible

absent choroid plexus ( J:67966 )

• choroid plexus absent by E12.5

abnormal trigeminal V mesencephalic nucleus morphology ( J:67966 )

• indistinctly formed

absent midbrain ( J:67966 )

• by E10.5 parts of the midbrain are missing

• no discernable midbrain by E12.5

abnormal telencephalon morphology ( J:67966 )

• enlarged telencephalon

• walls of cephalic vesicles thinner

abnormal hindbrain morphology ( J:67966 )

• anterior hindbrain is missing by E10.5

• poorly formed connections between cranial ganglia and hindbrain

absent cerebellum ( J:67966 )

• cerebellum is missing at E12.5

absent metencephalon ( J:67966 )

• anterior hindbrain is missing by E10.5

abnormal cranial nerve morphology ( J:67966 )

abnormal facial nerve morphology ( J:67966 )

• combined ganglion with vestibulocochlear nerve abnormal

abnormal glossopharyngeal nerve morphology ( J:67966 )

• roots poorly formed

abnormal hypoglossal nerve morphology ( J:67966 )

• roots poorly formed

• hypoglossal nerve missing

absent oculomotor nerve ( J:67966 )

abnormal vagus nerve morphology ( J:67966 )

• roots poorly formed

abnormal dorsal root ganglion morphology ( J:67966 )

• first spinal root ganglion missing

• other spinal root ganglia severely affected as well

embryo

abnormal neural tube morphology ( J:67966 )

• shortened neural tube