Phenotypes Associated with This Genotype

Genotype
MGI:2673649

• Allelic Composition: Egfr^tm2(EGFR)Wag/Egfr^tm2(EGFR)Wag
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84870 )

• increased lethality prior to 6 months of age due to cardiac hypertrophy

prenatal lethality, incomplete penetrance ( J:84870 )

• incomplete penetrance, 7% of homozygous mutant mice were born alive

cardiovascular system

cardiac hypertrophy ( J:84870 )

• contributing to increased lethality

• apparent 3 weeks after birth in some mice

heart left ventricle hypertrophy ( J:84870 )

abnormal semilunar valve morphology ( J:84870 )

growth/size/body

cardiac hypertrophy ( J:84870 )

• contributing to increased lethality

• apparent 3 weeks after birth in some mice

heart left ventricle hypertrophy ( J:84870 )

decreased body size ( J:84870 )

decreased body weight ( J:84870 )

postnatal growth retardation ( J:84870 )

skeleton

enhanced osteoblast differentiation ( J:84870 )

• accelerated osteoblast differentiation

premature chondrocyte differentiation ( J:84870 )

• accelerated chondrocyte differentiation

nervous system

nervous system phenotype ( J:84870 )

N • in contrast to null mice, normal architecture and morphology was observed in various sections of the brain including the frontal cortex, hippocampus, olfactory bulb, thalamus, and cerebellum

integument

alopecia ( J:84870 )

• by 5 to 7 months of age due to progressive degeneration of hair follicles

delayed hair appearance ( J:84870 )

short hair ( J:84870 )

sparse hair ( J:84870 )

abnormal hair follicle orientation ( J:84870 )

decreased hair follicle number ( J:84870 )

• progressive degeneration and inflammation led to the loss of most follicles over time, leading to baldness by 5 to 7 months of age

curly vibrissae ( J:84870 )

abnormal hair cycle ( J:84870 )

cellular

enhanced osteoblast differentiation ( J:84870 )

• accelerated osteoblast differentiation

muscle

heart left ventricle hypertrophy ( J:84870 )