Phenotypes Associated with This Genotype

Genotype
MGI:2673303

• Allelic Composition: Cd3g^tm1Amk/Cd3g^tm1Amk
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:77504 )

• reduced thymic cellularity

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

abnormal T cell differentiation ( J:77504 )

• defective alpha-beta and gamma-delta T cell development

abnormal T cell physiology ( J:77504 )

• attenuated T cell response, putatively due to a decrease in the surface expression of mature TCR complexes

abnormal CD8-positive, alpha-beta T cell physiology ( J:77504 )

• expansion of an antigen-specific CD8 T cell population is completely abrogated after infection with influenza A virus

decreased cytotoxic T cell cytolysis ( J:77504 )

• polyclonal induction of cytotoxic T-cell activity under suboptimal conditions results in a reduction in the proliferative response of T cells and completely abolishes cytolytic activity of the effector T cells

abnormal T cell activation ( J:77504 )

• reduced T cell activation in response to anti-CD3epsilon mAb

abnormal T cell proliferation ( J:77504 )

• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression

lymph node hypoplasia ( J:77504 )

• reduced lymph node cellularity

hematopoietic system

thymus hypoplasia ( J:77504 )

• reduced thymic cellularity

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

abnormal T cell differentiation ( J:77504 )

• defective alpha-beta and gamma-delta T cell development

abnormal T cell physiology ( J:77504 )

• attenuated T cell response, putatively due to a decrease in the surface expression of mature TCR complexes

abnormal CD8-positive, alpha-beta T cell physiology ( J:77504 )

• expansion of an antigen-specific CD8 T cell population is completely abrogated after infection with influenza A virus

decreased cytotoxic T cell cytolysis ( J:77504 )

• polyclonal induction of cytotoxic T-cell activity under suboptimal conditions results in a reduction in the proliferative response of T cells and completely abolishes cytolytic activity of the effector T cells

abnormal T cell activation ( J:77504 )

• reduced T cell activation in response to anti-CD3epsilon mAb

abnormal T cell proliferation ( J:77504 )

• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression

endocrine/exocrine glands

thymus hypoplasia ( J:77504 )

• reduced thymic cellularity

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

cellular

abnormal T cell proliferation ( J:77504 )

• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression