Phenotypes Associated with This Genotype

Genotype
MGI:2673253

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Tg(Pou3f4-cre)32Cren/?
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:83935 )

• increased proliferation of cells by E10

• 110% at E11 to 300% at E11.5

• E11 proliferation rate increased 1.4X

• 6.7% increase in progenitor cell death and apoptosis

• lower proportion of differentiated neurons to proliferative cells

abnormal brain morphology ( J:83935 )

increased brain size ( J:83935 )

• changes similar to those seen in the spinal cord

• tissue mass of the midbrain was increased

• increased proliferation in all areas of the brain

• progenitor domains of the midbrain and other areas of the brain increased

• increased apoptosis

increased spinal cord size ( J:83935 )

• enlarged ventricular zone at E10.5

• increased area occupied by neural progenitor cells

• smaller area occupied by differentiated neurons (as determined immunohistochemically and by activity of genes expressed in progenitor cells)