Phenotypes Associated with This Genotype

Genotype
MGI:2673004

• Allelic Composition: Nanog^tm1Yam/Nanog^tm1Yam
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:83420 )

• no mice homozygous for this allele were born from heterozygous intercrosses

• at E3.5 homozygous embryos are indistinguishable from normal embryos; however, no homozygous embryos were present at E7.5

embryo

absent embryonic epiblast ( J:83420 )

• at E5.5, embryos presumably homozygous had no discernable epiblast

absent extraembryonic ectoderm ( J:83420 )

• at E5.5, embryos presumably homozygous had no extraembryonic ectoderm

disorganized extraembryonic tissue ( J:83420 )

• at E5.5, embryos presumably homozygous were made entirely of disorganized extraembryonic tissue