About   Help   FAQ
Targeted Allele Detail
Symbol: Nanogtm1Yam
Name: Nanog homeobox; targeted mutation 1, Shinya Yamanaka
MGI ID: MGI:2664492
Synonyms: Nanog-
Gene: Nanog  Location: Chr6:122684448-122691592 bp, + strand  Genetic Position: Chr6, 57.8 cM, cytoband F2
Alliance: Nanogtm1Yam page
Germline Transmission:  Earliest citation of germline transmission: J:83420
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 of the gene, which contains the homeodomain, was replaced with an IRES-Beta geo cassette. X-gal staining of preimplantation embryos detected beta-geo in the inner cell mass of blastocysts and the central portion of the morula but not in 32-cell stage embryos or earlier. (J:83420)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanog Mutation:  44 strains or lines available
Original:  J:83420 Mitsui K, et al., The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory