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Nanogtm1Yam
Targeted Allele Detail
Summary
Symbol: Nanogtm1Yam
Name: Nanog homeobox; targeted mutation 1, Shinya Yamanaka
MGI ID: MGI:2664492
Synonyms: Nanog-
Gene: Nanog  Location: Chr6:122684448-122691592 bp, + strand  Genetic Position: Chr6, 57.8 cM, cytoband F2
Alliance: Nanogtm1Yam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83420
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 of the gene, which contains the homeodomain, was replaced with an IRES-Beta geo cassette. X-gal staining of preimplantation embryos detected beta-geo in the inner cell mass of blastocysts and the central portion of the morula but not in 32-cell stage embryos or earlier. (J:83420)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanog Mutation:  44 strains or lines available
References
Original:  J:83420 Mitsui K, et al., The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory