Phenotypes Associated with This Genotype

Genotype
MGI:2672838

• Allelic Composition: Cd9^tm1Mek/Cd9^tm1Mek
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:260669 )

♀ • eggs show reduced surface expression of IGSF8 (immunoglobulin superfamily, member 8) relative to wild-type eggs

female infertility ( J:59402 )

♀ • ovaries normal

♀ • about 2% of normal number of pups born

♀ • failure of eggs to fuse with sperm and form pronuclei

♀ • males have normal fertility

hematopoietic system

abnormal definitive hematopoiesis ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

cellular

abnormal oocyte morphology ( J:260669 )

♀ • eggs show reduced surface expression of IGSF8 (immunoglobulin superfamily, member 8) relative to wild-type eggs