Phenotypes Associated with This Genotype

Genotype
MGI:2672139

• Allelic Composition: Rad51d^tm1Jcs/Rad51d^tm1Jcs
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Delayed development and turning, posterior truncation, brain vesicle and limb bud defects in Rad51d^tm1Jcs/Rad51d^tm1Jcs embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:61460 )

• no homozygous pups are born in matings of heterozygous parents

• no homozygous embryos are found after E10.5

cardiovascular system

pericardial edema ( J:61460 )

• may be pericardial swelling

cellular

decreased cellular sensitivity to methylmethanesulfonate ( J:61460 )

• blastocysts have reduced sensitivity to cell death induced by methylmethanesulfonate

decreased cellular sensitivity to gamma-irradiation ( J:61460 )

• blastocysts have reduced sensitivity to cell death induced by gamma-irradiation

embryo

abnormal developmental patterning ( J:61460 )

abnormal embryo turning ( J:61460 )

• usually fail to undergo turning

• if turning does occur then neural folds also close and heart looping is seen

caudal body truncation ( J:61460 )

• posterior truncation

embryonic growth retardation ( J:61460 )

abnormal limb bud morphology ( J:61460 )

• developing limb buds are disorganized at the cellular level with high numbers of pycnotic nuclei

abnormal neural tube morphology ( J:61460 )

• decreased brain vesicle size

nervous system

abnormal neural tube morphology ( J:61460 )

• decreased brain vesicle size

limbs/digits/tail

abnormal limb bud morphology ( J:61460 )

• developing limb buds are disorganized at the cellular level with high numbers of pycnotic nuclei

growth/size/body

embryonic growth retardation ( J:61460 )

homeostasis/metabolism

pericardial edema ( J:61460 )

• may be pericardial swelling