Phenotypes Associated with This Genotype

Genotype
MGI:2670767

• Allelic Composition: Pafah1b1^tm1Awb/Pafah1b1⁺; Ywhae^tm1Awb/Ywhae⁺
• Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

abnormal brain morphology ( J:84075 )

abnormal hippocampus morphology ( J:84075 )

• very severe abnormalities in pyramidal cell packing as compared to mice heterozygous at only one of these two loci

cellular

abnormal neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lissencephaly		DOID:0050453	OMIM:PS607432	J:84075
Miller-Dieker lissencephaly syndrome		DOID:0060469	OMIM:247200	J:84075