Mouse Genome Informatics
hm
    Ywhaetm1Awb/Ywhaetm1Awb
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most homozygotes died at birth
• 2.5% on mixed background survived
• 1% on inbred background survived
• survivors small but otherwise normal

nervous system
• neuronal migration distances for brain neurons are shorter than in wild-type
• increased apoptosis
• ventricular zone proliferation is normal
• pyramidal cell layer is disorganized and less cellular
• cortex is thinner than normal

cellular
• neuronal migration distances for brain neurons are shorter than in wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Miller-Dieker Lissencephaly Syndrome; MDLS 247200 J:84075