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Phenotypes Associated with This Genotype
Genotype
MGI:2670755
Allelic
Composition
Ywhaetm1Awb/Ywhaetm1Awb
Genetic
Background
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ywhaetm1Awb mutation (1 available); any Ywhae mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes died at birth (J:84075)
• 2.5% on mixed background survived (J:84075)
• 1% on inbred background survived (J:84075)
• survivors small but otherwise normal (J:84075)
• most homozygotes died at birth (J:84075)
• 2.5% on mixed background survived (J:84075)
• 1% on inbred background survived (J:84075)
• survivors small but otherwise normal (J:84075)

nervous system
• neuronal migration distances for brain neurons are shorter than in wild-type (J:84075)
• neuronal migration distances for brain neurons are shorter than in wild-type (J:84075)
• increased apoptosis (J:84075)
• ventricular zone proliferation is normal (J:84075)
• increased apoptosis (J:84075)
• ventricular zone proliferation is normal (J:84075)
• pyramidal cell layer is disorganized and less cellular (J:84075)
• pyramidal cell layer is disorganized and less cellular (J:84075)
• cortex is thinner than normal (J:84075)
• cortex is thinner than normal (J:84075)

cellular
• neuronal migration distances for brain neurons are shorter than in wild-type (J:84075)
• neuronal migration distances for brain neurons are shorter than in wild-type (J:84075)

Mouse Models of Human Disease
OMIM ID Ref(s)
Miller-Dieker Lissencephaly Syndrome; MDLS 247200 J:84075


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory