About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2670755
Allelic
Composition
Ywhaetm1Awb/Ywhaetm1Awb
Genetic
Background
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ywhaetm1Awb mutation (1 available); any Ywhae mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes died at birth
• 2.5% on mixed background survived
• 1% on inbred background survived
• survivors small but otherwise normal

nervous system
• neuronal migration distances for brain neurons are shorter than in wild-type
• increased apoptosis
• ventricular zone proliferation is normal
• pyramidal cell layer is disorganized and less cellular
• cortex is thinner than normal

cellular
• neuronal migration distances for brain neurons are shorter than in wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Miller-Dieker Lissencephaly Syndrome; MDLS 247200 J:84075


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory