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Phenotypes Associated with This Genotype
Genotype
MGI:2670741
Allelic
Composition		 Ksr1tm1Kole/Ksr1tm1Kole
Tg(Hba-x-v-Ha-ras)TG.ACLed/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ksr1tm1Kole mutation (0 available); any Ksr1 mutation (50 available)
Tg(Hba-x-v-Ha-ras)TG.ACLed mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:84644 )
• only 10% of TPA-treated homozygotes carrying the Tg(Hba-x-v-Ha-ras)TG.ACLed transgene develop Ras-induced papillomas versus 70% of wild-type, transgene-positive control mice, with a similar average number of papillomas (2-4 per mouse) in each group

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:84644 )
• only 10% of TPA-treated homozygotes carrying the Tg(Hba-x-v-Ha-ras)TG.ACLed transgene develop Ras-induced papillomas versus 70% of wild-type, transgene-positive control mice, with a similar average number of papillomas (2-4 per mouse) in each group

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory