Phenotypes Associated with This Genotype

Genotype
MGI:2670217

• Allelic Composition: Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac

abnormal definitive hematopoiesis ( J:84564 )

• increase in the number of hematopoietic progenitor cells in the yolk sac, fetal liver, and bone marrow

• 1.5-fold increase in colony forming unit numbers and colony size from adult spleen cells

anemia ( J:84564 )

• observed in some mice due to a bleeding tendancy

thrombocytopenia ( J:84564 )

• thrombocytopenia is some mice

increased hematopoietic stem cell number ( J:84564 )

• 1.5- to 2-fold increase in hematopoietic progenitors in the adult bone marrow

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

homeostasis/metabolism

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

cellular

abnormal cell adhesion ( J:84564 )

• adhesion of bone marrow cells to fibronectin is impaired

embryo

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac