Phenotypes Associated with This Genotype

Genotype
MGI:2669895

• Allelic Composition: Hcrtr2^tm1Ywa/Hcrtr2^tm1Ywa
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sleep pattern ( J:83817 )

• wakefulness is disrupted, with mice showing higher frequencies of awake episodes during the light and dark phases and severely diminished durations of wakefulness episodes over the entire dark phase and fragmentation of vigilance states

abnormal non-rapid eye movement sleep pattern ( J:83817 )

• non-REM sleep is disrupted, with mice showing higher frequencies of non-REM sleep episodes during the dark phase

• reduction in durations of non-REM sleep, especially at night

abnormal paradoxical sleep pattern ( J:83817 )

• mice show a reduced REM sleep latency during the dark phase

narcolepsy ( J:83817 )

• episodes of gradual cessation of purposeful activity and a transition to non-REM sleep leading quickly to REM sleep

• rare episodes of abrupt cessation of purposeful activity and a transition directly to REM sleep with associated muscle atonia (cataplexy)

• abrupt arrests are associated with emotive motor activity such as vigorous grooming, ambulation and climbing while gradual arrests are preceded by quiet wakefulness

• gradual arrests are occasionally accompanied by automatic behavior such as stereotypic continued chewing of food after the onset of non-REM sleep

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
narcolepsy		DOID:8986	OMIM:161400 OMIM:605841 OMIM:609039 OMIM:612417 OMIM:612851 OMIM:614223 OMIM:614250	J:83817