Phenotypes for Pafah1b1 Pafah1b2 Pafah1b3 MGI:2669856 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pafah1b1^tm1Awb/Pafah1b1⁺ Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b3^tm1Cla/Pafah1b3^tm1Cla
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (158 available)
Pafah1b2^{Gt(Betageo)1Cla} mutation (0 available); any Pafah1b2 mutation (20 available)
Pafah1b3^tm1Cla mutation (0 available); any Pafah1b3 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

reproductive system

reproductive system phenotype ( J:83818 )

N	• males are fertile

decreased male germ cell number ( J:83818 )

• some degenerating germ cells are seen

multinucleated giant male germ cells ( J:83818 )

abnormal seminiferous tubule epithelium morphology ( J:83818 )

• occasional multinucleated giant cells are seen in the seminiferous epithelium

decreased testis weight ( J:83818 )

• testis weigh about 20% less than that of control mice

cellular