Phenotypes Associated with This Genotype

Genotype
MGI:2669854

• Allelic Composition: Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla}; Pafah1b3^tm1Cla/Pafah1b3^tm1Cla
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

reproductive system

decreased male germ cell number ( J:83818 )

♂ • germ cell depletion is more severe than in the single Pafah1b2 homozygote

multinucleated giant male germ cells ( J:83818 )

♂ • multinucleated giant cells are seen in the seminiferous epithelium

abnormal testis morphology ( J:83818 )

♂ • testis tubular structures are less obvious and the lumen is small

decreased testis weight ( J:83818 )

♂ • testis weigh about 30% of that of control mice

abnormal sperm number ( J:83818 )

♂

arrest of spermatogenesis ( J:83818 )

♂ • disruption occurs at the initiation phase of spermatogenesis

male infertility ( J:83818 )

♂ • males are infertile, however female fertility is unaffected

endocrine/exocrine glands

abnormal testis morphology ( J:83818 )

♂ • testis tubular structures are less obvious and the lumen is small

decreased testis weight ( J:83818 )

♂ • testis weigh about 30% of that of control mice

cellular

decreased male germ cell number ( J:83818 )

♂ • germ cell depletion is more severe than in the single Pafah1b2 homozygote

multinucleated giant male germ cells ( J:83818 )

♂ • multinucleated giant cells are seen in the seminiferous epithelium