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Phenotypes Associated with This Genotype
Genotype
MGI:2669009
Allelic
Composition
Wt1tm1Jae/Wt1tm1Jae
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1Jae mutation (3 available); any Wt1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 16% of homozygous offsrping from intercrosses of heterozygous F1 mice survive to birth, but died immediately after due to impaired lung inflation
• some embryos die in utero

muscle
• abnormal primordial diaphragm with the caudal and more anterior aspect unilaterally missing
• left-sided posterolateral defects
• however, some mice had no diaphragmatic hernias

respiratory system

endocrine/exocrine glands
• observed at E18.5 in mice on a background involving MF1

hematopoietic system
• increased apoptosis of primordial spleen cells
• spleen primordium is smaller at E13.5 and the connection to the prospective pancreas is shortened
• at E15.5, only some thickening of the mesogastrium is observed and not a well-developed spleen as in wild-type
• stromal cells fo the spleen fail to develop
• almost complete absence of the spleen, correlated with increased apoptosis of primordial spleen cells

immune system
• increased apoptosis of primordial spleen cells
• spleen primordium is smaller at E13.5 and the connection to the prospective pancreas is shortened
• at E15.5, only some thickening of the mesogastrium is observed and not a well-developed spleen as in wild-type
• stromal cells fo the spleen fail to develop
• almost complete absence of the spleen, correlated with increased apoptosis of primordial spleen cells

cellular
• increased apoptosis of primordial spleen cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital diaphragmatic hernia DOID:3827 OMIM:142340
OMIM:222400
OMIM:610187
J:114565


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory