Phenotypes Associated with This Genotype

Genotype
MGI:2668420

• Allelic Composition: Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm4Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:84300 )

• embryos develop severe anterior truncations at E8.5

embryo

rostral body truncation ( J:84300 )

• embryos develop severe anterior truncations at E8.5

abnormal embryonic neuroepithelium morphology ( J:84300 )

• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei

cardiovascular system

abnormal heart looping ( J:84300 )

• heart tube is abnormally looped

pericardial edema ( J:84300 )

• pericardium is often edematous

enlarged pericardium ( J:84300 )

• pericardium is often enlarged

digestive/alimentary system

abnormal foregut morphology ( J:84300 )

• gut tube forms but is poorly elaborated in anterior region; instead of extending to level of Rathke's pouch like wild-type, no gut tissue is evident at this level in mutants and is absent anterior to level of heart

homeostasis/metabolism

pericardial edema ( J:84300 )

• pericardium is often edematous

nervous system

abnormal embryonic neuroepithelium morphology ( J:84300 )

• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei

absent midbrain ( J:84300 )

• midbrain regions are not specified

absent forebrain ( J:84300 )

• forebrain regions are not specified

decreased embryonic neuroepithelial cell proliferation ( J:84300 )

• the anterior neurectoderm fails to proliferate