Phenotypes Associated with This Genotype

Genotype
MGI:2665858

• Allelic Composition: Blnk^tm1Dkit/Blnk^tm1Dkit; Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:84040 )

• pre-B cell leukemia

hematopoietic system

enlarged spleen ( J:84040 )

absent immature B cells ( J:84040 )

• immature B cells are absent in the spleen

arrested B cell differentiation ( J:84040 )

• complete arrest at the pre-B cell transition

absent mature B cells ( J:84040 )

• mature B cells are absent in the spleen

abnormal pre-B cell morphology ( J:84040 )

• dominating large pre-B cells are noncycling

decreased pre-B cell number ( J:84040 )

• very few pre-B cells (B220^dull)

immune system

enlarged spleen ( J:84040 )

absent immature B cells ( J:84040 )

• immature B cells are absent in the spleen

arrested B cell differentiation ( J:84040 )

• complete arrest at the pre-B cell transition

absent mature B cells ( J:84040 )

• mature B cells are absent in the spleen

abnormal pre-B cell morphology ( J:84040 )

• dominating large pre-B cells are noncycling

decreased pre-B cell number ( J:84040 )

• very few pre-B cells (B220^dull)

enlarged lymph nodes ( J:84040 )

growth/size/body

enlarged spleen ( J:84040 )