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Phenotypes Associated with This Genotype
Genotype
MGI:2665504
Allelic
Composition
ApcMin/Apc+
Genetic
Background
C57BL/6J-ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (116 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Rab25tm1Jrgo/Rab25tm1Jrgo ApcMin/Apc+ mice exhibit increased intestinal adenoma formation compared to ApcMin/Apc+ mice

mortality/aging
• average lifespan is 118 +/- 26 days
• Background Sensitivity: life span is reduced compared to mice on an (MA/MyJ x C57BL/6J-Apc)F1 or (AKR/J x C57BL/6J-Apc)F1 background

neoplasm
• develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis (J:1879)
• serotonergic cells were found in 18 of 18 adenomas (J:1879)
• most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter (J:85142)
• mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15 (J:85142)
• at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males (J:85142)
• mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet (J:85142)
• tubular adenomas in the intestine (J:158733)
• mice treated with a novel TNIK inhibitor NCB-0846 show reduced multiplicity and size of tumors that develop in the small intestine (J:241611)
• tubular adenomas in the colon (J:158733)

digestive/alimentary system
• develop adenomatous polyps with moderate dysplasia, mild nuclear atypia and frequent mitotic figures throughout the duodenal-to-colonic axis (J:1879)
• serotonergic cells were found in 18 of 18 adenomas (J:1879)
• most mutants exhibit a few small or medium-sized adenomas at 5 weeks of age, with numbers increasing significantly between 5 and 8 weeks and then staying at the same level thereafter (J:85142)
• mean diameter of adenomas and adenoma burden increases significantly between weeks 5 and 8 and between weeks 8 and 15 (J:85142)
• at 8 and 15 weeks of age, females have proportionally more small adenomas and fewer medium-sized adenomas than males (J:85142)
• mice fed a beef or inulin diet develop a similar number of adenomas as mice fed the rodent chow diet (J:85142)
• tubular adenomas in the intestine (J:158733)
• mice treated with a novel TNIK inhibitor NCB-0846 show reduced multiplicity and size of tumors that develop in the small intestine (J:241611)
• tubular adenomas in the colon (J:158733)

homeostasis/metabolism
• females exhibit increased free fatty acid levels at 15 weeks of age
• females show increased triglyceride levels at 15 weeks of age
• increase in luminal prostaglandin E2 at 15 weeks of age

liver/biliary system
• centrilobular-restricted steatosis is seen in the livers of mutants at 15 weeks of age

growth/size/body
• regular chow-fed males stop gaining weight, lose more weight, and are smaller at 15 weeks than beef-fed males

hematopoietic system
• fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments
• however, luminal IgA, IL-12, and TNF-alpha concentrations are normal

immune system
• fewer Mac-1+ (macrophages) cells in ileal mucosa at 5 weeks of age, however numbers are normal at later time points and in all dietary treatments
• however, luminal IgA, IL-12, and TNF-alpha concentrations are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory