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Phenotypes Associated with This Genotype
Genotype
MGI:2665288
Allelic
Composition
Tg(Ins1-GAS)1Sbr/0
Genetic
Background
involves: FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins1-GAS)1Sbr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• total number of azoxymethane (AOM)-induced adenocarcinomas per colon is slightly higher than in wild-type, however no mutants died after AOM treatment compared to 20% f wild-type
• all mice older than 20 months of age exhibit intramucosal dysplasia and most older mice have intramucosal carcinomas
• majority of mice followed up to 20 months of age develop gastric carcinomas that invade the submucosa, muscularis, and vasculature
• however, no evidence of metastases to lymph nodes or other tissues is seen
• mice infected with Heliobacter felis at 4 weeks of age exhibit accelerated progression to gastric carcinoma, with 85% developing intramucosal carcinoma, with submucosal invasion in 54% of mice, and intravascular invasion in 46% of mice

homeostasis/metabolism
• mice initially show mild hypergastrinemia that develops into moderate hypergastrinemia with age (J:59575)
• blood levels of gastrin are higher than in wild-type (J:63579)
• total number of azoxymethane (AOM)-induced adenocarcinomas per colon is slightly higher than in wild-type, however no mutants died after AOM treatment compared to 20% f wild-type

digestive/alimentary system
• mice exhibit intestinal metaplasia at 20 months of age
• mice develop foveolar hyperplasia and thickened gastric folds
• small increase in the number of enterochromaffin-like (ECL) cells at 1 month of age
• ECL cell numbers decrease by 12 months of age and show an altered distribution with increasing numbers in the upper half of the gastric glands
• hypertrophy of the oxyntic glands at 20 months of age, caused primarily by foveolar hyperplasia
• increase in the number of parietal cells at 2 and 3 months of age
• parietal cell numbers decrease to less than 68% of normal by 10 months of age and less than 40% of normal by 12 months and only a small number of parietal cells are present at 20 months
• expansion of surface mucous cells in the gastric pit region leading to an overall increase in mucosal thickness
• mice exhibit gastric hypertrophy at 20 months of age; hypertrophy involves only the fundus of the stomach
• mice exhibit a 2-3-fold increase in stimulated gastric acid secretion at 1 and 4 months of age
• mice 5 months and older show a decline in the level of stimulated acid secretion, with significantly lower level of acid secretion at 12 months of age and no acid secretion at 20 months of age

endocrine/exocrine glands
• small increase in the number of enterochromaffin-like (ECL) cells at 1 month of age
• ECL cell numbers decrease by 12 months of age and show an altered distribution with increasing numbers in the upper half of the gastric glands
• hypertrophy of the oxyntic glands at 20 months of age, caused primarily by foveolar hyperplasia
• increase in the number of parietal cells at 2 and 3 months of age
• parietal cell numbers decrease to less than 68% of normal by 10 months of age and less than 40% of normal by 12 months and only a small number of parietal cells are present at 20 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
stomach cancer DOID:10534 OMIM:137215
OMIM:613659
J:59575


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory