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Phenotypes Associated with This Genotype
Genotype
MGI:2665040
Allelic
Composition
Fshbtm1Zuk/Fshbtm1Zuk
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fshbtm1Zuk mutation (1 available); any Fshb mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 30% decrease in the number of Sertoli cells relative to wild-type
• 60% reduction in weight relative to wild-type

reproductive system
• decline in germ cell numbers that becomes more marked as spermatogenesis progresses; 46% reduction in A and I spermatogonia and a 60% reduction in round spermatids
• 46% reduction in A and I spermatogonia
• 30% decrease in the number of Sertoli cells relative to wild-type
• 60% reduction in weight relative to wild-type
• lower Sertoli cell to round spermatid ratio
• decrease in the ratios of spermatogonia and early stages of the first meiotic prophase (preleptotene, leptotene, and zygotene) to the later stages of meiotic prophase (pachytene and diplotene) and of pachytene/diplotene spermatocyte to round round spermatids, indicating impaired spermatogenesis
• 60% reduction in round spermatids

cellular
• decline in germ cell numbers that becomes more marked as spermatogenesis progresses; 46% reduction in A and I spermatogonia and a 60% reduction in round spermatids
• 60% reduction in round spermatids
• 46% reduction in A and I spermatogonia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory