endocrine/exocrine glands
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• 30% decrease in the number of Sertoli cells relative to wild-type
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• 60% reduction in weight relative to wild-type
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reproductive system
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• decline in germ cell numbers that becomes more marked as spermatogenesis progresses; 46% reduction in A and I spermatogonia and a 60% reduction in round spermatids
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• 46% reduction in A and I spermatogonia
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• 30% decrease in the number of Sertoli cells relative to wild-type
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• 60% reduction in weight relative to wild-type
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• lower Sertoli cell to round spermatid ratio
• decrease in the ratios of spermatogonia and early stages of the first meiotic prophase (preleptotene, leptotene, and zygotene) to the later stages of meiotic prophase (pachytene and diplotene) and of pachytene/diplotene spermatocyte to round round spermatids, indicating impaired spermatogenesis
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• 60% reduction in round spermatids
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cellular
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• decline in germ cell numbers that becomes more marked as spermatogenesis progresses; 46% reduction in A and I spermatogonia and a 60% reduction in round spermatids
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• 60% reduction in round spermatids
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• 46% reduction in A and I spermatogonia
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