Phenotypes Associated with This Genotype

Genotype
MGI:2665007

• Allelic Composition: Wt1^tm1Jae/Wt1^tm1Jae
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:14317 )

• death between E13 and E15; no homozygous embryos are recovered after E15.5

cardiovascular system

cardiovascular system phenotype ( J:14317 )

N • normal aortic, pulmonary, mitral, and tricuspid valves

N • normal atrial and ventricular septa

abnormal heart apex morphology ( J:14317 )

• rounded apex

small heart ( J:14317 )

hemopericardium ( J:14317 )

• small amount of pericardial blood observed in some mice

embryo

increased metanephric mesenchyme apoptosis ( J:14317 )

• degeneration of the metaneprhic blastema observed at E12

• apoptosis in 10 to 50% of the cells of the metanephric blastema

abnormal embryonic tissue morphology ( J:14317 )

abnormal gonadal ridge morphology ( J:14317 )

• retarded development of the gonadal ridge followed by arrest around E14

homeostasis/metabolism

hemopericardium ( J:14317 )

• small amount of pericardial blood observed in some mice

edema ( J:14317 )

• systemic edema

muscle

diaphragmatic hernia ( J:14317 )

• incomplete development resulting in the herniation of lung tissue into the abdominal cavity

renal/urinary system

abnormal kidney development ( J:14317 )

• arrested development

increased metanephric mesenchyme apoptosis ( J:14317 )

• degeneration of the metaneprhic blastema observed at E12

• apoptosis in 10 to 50% of the cells of the metanephric blastema

respiratory system

abnormal lung development ( J:14317 )

• impeded growth, putatively due to incomplete pleura expansion

cellular

increased metanephric mesenchyme apoptosis ( J:14317 )

• degeneration of the metaneprhic blastema observed at E12

• apoptosis in 10 to 50% of the cells of the metanephric blastema