Phenotypes for Esr1 Esr2 MGI:2664687 MGI Mouse

reproductive system

oligozoospermia ( J:59105 )

• 80% reduction in epididymal sperm count relative to wild-type

asthenozoospermia ( J:59105 )

• 5% reduction in the motility of sperm obtained from the epididymis

abnormal ovary morphology ( J:59105 )

• postnatal transdifferentiation of portions of the ovary, resulting in structures resembling seminiferous tubules

• these tubule-like structures contained degenerating granulosa cells, sertoli-like cells, and in some cases, degenerating oocytes

absent corpus luteum ( J:59105 )

uterus hypoplasia ( J:59105 )

• evident at 2.5 to 7 months of age

• however, normal development of Mullerian-derived structures (uterus, cervix, and upper vagina) is seen

female infertility ( J:59105 )

male infertility ( J:59105 )

skeleton

long femur ( J:111108 )

• at 4, 9, and 18 months, femur length is increased compared to in Esr1^tm1Ksk homozygotes

abnormal vertebrae morphology ( J:111108 )

• at 18 months, vertebra height is increased compared to in to Esr1^tm1Ksk homozygotes

endocrine/exocrine glands

abnormal ovary morphology ( J:59105 )

• postnatal transdifferentiation of portions of the ovary, resulting in structures resembling seminiferous tubules

• these tubule-like structures contained degenerating granulosa cells, sertoli-like cells, and in some cases, degenerating oocytes

absent corpus luteum ( J:59105 )

homeostasis/metabolism

• higher than those observed in Esr1^tm1Ksk homozygous mice

growth/size/body

increased body length ( J:111108 )

• at 9 and 18 months, crown to rump length is increased compared to Esr1^tm1Ksk homozygotes

limbs/digits/tail