Phenotypes Associated with This Genotype

Genotype
MGI:2664411

• Allelic Composition: Cd28^tm1Pjl/Cd28^tm1Pjl; Tg(DO11.10)10Dlo/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:25536 )

abnormal T cell proliferation ( J:25536 )

• naive T cells are able to initiate a response to antigen but show decreased sensitivity to lower antigen concentrations and are unable to maintain their proliferative response

• naive CD4+ antigen-specific T cell responses to mitogen (Con A) activation are reduced in splenocytes

abnormal thymocyte activation ( J:25536 )

• thymocyte proliferative responses to OVA antigen are reduced

decreased interleukin-2 secretion ( J:25536 )

• 10- to 20-fold decrease in T cell IL-2 production when stimulated with OVA antigen

hematopoietic system

abnormal T cell activation ( J:25536 )

abnormal T cell proliferation ( J:25536 )

• naive T cells are able to initiate a response to antigen but show decreased sensitivity to lower antigen concentrations and are unable to maintain their proliferative response

• naive CD4+ antigen-specific T cell responses to mitogen (Con A) activation are reduced in splenocytes

abnormal thymocyte activation ( J:25536 )

• thymocyte proliferative responses to OVA antigen are reduced

endocrine/exocrine glands

abnormal thymocyte activation ( J:25536 )

• thymocyte proliferative responses to OVA antigen are reduced

cellular

abnormal T cell proliferation ( J:25536 )

• naive T cells are able to initiate a response to antigen but show decreased sensitivity to lower antigen concentrations and are unable to maintain their proliferative response

• naive CD4+ antigen-specific T cell responses to mitogen (Con A) activation are reduced in splenocytes