Phenotypes Associated with This Genotype

Genotype
MGI:2664297

• Allelic Composition: Gnb5^tm1Ck/Gnb5^tm1Ck
• Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S/SvEv * 129S1/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:83620 )

• >66% of homozygotes die before weaning, mostly between P15 and P20

• preweaning mortality can be bypassed by initiating hand-feeding at P2 with homozygotes surviving to adulthood

growth/size/body

decreased body size ( J:83620 )

• mutant pups appear runted relative to wild-type pups

slow postnatal weight gain ( J:83620 )

• homozygotes exhibit a slower weight gain in the first month of life relative to wild-type controls

• a period of no weight gain is observed from P15 to P20

nervous system

nervous system phenotype ( J:83620 )

N • surprisingly, surviving homozygotes display no gross defects in brain morphology at 3 months of age

vision/eye

vision/eye phenotype ( J:83620 )

N • surprisingly, surviving homozygotes display no gross defects in retina morphology at 3 months of age