Phenotypes Associated with This Genotype

Genotype
MGI:2663872

• Allelic Composition: Mlh1^tm1Lisk/Mlh1^tm1Lisk
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lymphoma incidence ( J:34291 )

• lymphoma was observed in a single female at 6 months of age

reproductive system

azoospermia ( J:34291 )

♂ • no spermatozoa in the epididymis

arrest of male meiosis ( J:34291 )

♂ • arrest occuring at late pacytene, metaphase, or both

♂ • premature separation of homologues, due to unsuccessful completion of recombination and chiasma formation

decreased corpora lutea number ( J:34291 )

♀

abnormal ovarian folliculogenesis ( J:34291 )

♀ • decreased number of ovarian follicles

small ovary ( J:34291 )

♀

female infertility ( J:34291 )

♀

male infertility ( J:34291 )

♂

endocrine/exocrine glands

decreased corpora lutea number ( J:34291 )

♀

abnormal ovarian folliculogenesis ( J:34291 )

♀ • decreased number of ovarian follicles

small ovary ( J:34291 )

♀

cellular

azoospermia ( J:34291 )

♂ • no spermatozoa in the epididymis

arrest of male meiosis ( J:34291 )

♂ • arrest occuring at late pacytene, metaphase, or both

♂ • premature separation of homologues, due to unsuccessful completion of recombination and chiasma formation