Phenotypes Associated with This Genotype

Genotype
MGI:2663723

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Notch2^tm2Hhi/Notch2^tm1.1Hhi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased transitional stage B cell number ( J:83476 )

• decrease in the number of T2 B cells

• almost complete absence of CD1d T2 B cells, the precursors of marginal zone B cells (pre-MZB)

abnormal spleen marginal zone morphology ( J:83476 )

• complete absence of the perifollicular rim consisting of IgM^hiIgD^lo cells in the spleen

absent marginal zone B cells ( J:83476 )

• near complete absence of marginal zone B cells in the spleen

immune system

decreased transitional stage B cell number ( J:83476 )

• decrease in the number of T2 B cells

• almost complete absence of CD1d T2 B cells, the precursors of marginal zone B cells (pre-MZB)

abnormal spleen marginal zone morphology ( J:83476 )

• complete absence of the perifollicular rim consisting of IgM^hiIgD^lo cells in the spleen

absent marginal zone B cells ( J:83476 )

• near complete absence of marginal zone B cells in the spleen