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Phenotypes Associated with This Genotype
Genotype
MGI:2663720
Allelic
Composition		 Notch2tm2Hhi/Notch2tm1.1Hhi
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm1.1Hhi mutation (1 available); any Notch2 mutation (97 available)
Notch2tm2Hhi mutation (1 available); any Notch2 mutation (97 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased marginal zone B cell number ( J:83476 )
• reduced number of marginal zone B cells in the spleen

immune system
immune system phenotype ( J:83476 )
N
• mutants exhibit normal T cell development
decreased marginal zone B cell number ( J:83476 )
• reduced number of marginal zone B cells in the spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory