Phenotypes Associated with This Genotype

Genotype
MGI:2663412

• Allelic Composition: Clu^tm1Jakh/Clu^tm1Jakh
• Genetic Background: involves: Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:65660 )

• after immunization with cardiac myosin, mutant hearts become pale and enlarged, mutants exhibit 3-fold greater heart tissue injury than wild-type

abnormal myocardium layer morphology ( J:65660 )

• 21 days after myocarditis initiation, mice show significant cardiac tissue injury than wild-type mice

abnormal myocardial fiber morphology ( J:65660 )

• after immunization, myocyte necrosis is observed in some animals

decreased myocardial fiber number ( J:65660 )

• 7 weeks following myocarditis, widespread loss of myocardial fibers is found in mutant hearts, whereas none is seen in wild-type controls

abnormal heart ventricle morphology ( J:65660 )

• ventricular damage in females is 6-fold greater than in wild-type females; males do not show as severe cardiac damage

decreased cardiac muscle contractility ( J:65660 )

• postmyocarditis heart function is impaired with decreased shortening fraction measured in mutants;

heart inflammation ( J:65660 )

• severe, diffuse inflammation with large inflammatory aggregates occurs after immunization with cardiac myosin

myocarditis ( J:65660 )

• severe myocarditis after immunization with cardiac myosin, more severe than in wild-type

muscle

abnormal myocardium layer morphology ( J:65660 )

• 21 days after myocarditis initiation, mice show significant cardiac tissue injury than wild-type mice

abnormal myocardial fiber morphology ( J:65660 )

• after immunization, myocyte necrosis is observed in some animals

decreased myocardial fiber number ( J:65660 )

• 7 weeks following myocarditis, widespread loss of myocardial fibers is found in mutant hearts, whereas none is seen in wild-type controls

decreased cardiac muscle contractility ( J:65660 )

• postmyocarditis heart function is impaired with decreased shortening fraction measured in mutants;

immune system

heart inflammation ( J:65660 )

• severe, diffuse inflammation with large inflammatory aggregates occurs after immunization with cardiac myosin

myocarditis ( J:65660 )

• severe myocarditis after immunization with cardiac myosin, more severe than in wild-type

homeostasis/metabolism

cardiac edema ( J:65660 )

• immunized mice show cardiac edema