Phenotypes Associated with This Genotype

Genotype
MGI:2662779

• Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan
• Genetic Background: involves: C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

irregular coat pigmentation ( J:4746 )

• homozygotes display pigmented ears and scrotum

• eye color is distinctively black but normal

white spotting ( J:4746 )

• homozygotes are black-eyed whites

hematopoietic system

macrocytic anemia ( J:4746 )

• homozygotes exhibit a mild macrocytic anemia

reproductive system

decreased oocyte number ( J:4746 )

♀ • in newborn homozygotes, the number of oocytes is reduced to 20% of that in heterozygotes

decreased male germ cell number ( J:4746 )

♂ • at P0, the germ cell number in homozygous mutant testes is reduced to 30% of that in heterozygotes

♂ • at P4, the male germ cell number is 50% of that in heterozygotes, suggesting a compensatory proliferation

♂ • by P13, spermatogonia development appears relatively unaffected

decreased primordial germ cell number ( J:4746 )

• at E8-E11, homozygotes display a decreased number of primordial germ cells relative to wild-type controls

impaired ovarian folliculogenesis ( J:4746 )

♀ • in young and adult homozygotes, ovarian follicle development is primarily arrested at the one-layered cuboidal stage

small ovary ( J:4746 )

♀ • neonatal mutant ovaries are significantly smaller than wild-type

female infertility ( J:4746 )

♀ • females, but not males, are sterile

endocrine/exocrine glands

impaired ovarian folliculogenesis ( J:4746 )

♀ • in young and adult homozygotes, ovarian follicle development is primarily arrested at the one-layered cuboidal stage

small ovary ( J:4746 )

♀ • neonatal mutant ovaries are significantly smaller than wild-type

integument

irregular coat pigmentation ( J:4746 )

• homozygotes display pigmented ears and scrotum

• eye color is distinctively black but normal

white spotting ( J:4746 )

• homozygotes are black-eyed whites

cellular

decreased oocyte number ( J:4746 )

♀ • in newborn homozygotes, the number of oocytes is reduced to 20% of that in heterozygotes

decreased male germ cell number ( J:4746 )

♂ • at P0, the germ cell number in homozygous mutant testes is reduced to 30% of that in heterozygotes

♂ • at P4, the male germ cell number is 50% of that in heterozygotes, suggesting a compensatory proliferation

♂ • by P13, spermatogonia development appears relatively unaffected

decreased primordial germ cell number ( J:4746 )

• at E8-E11, homozygotes display a decreased number of primordial germ cells relative to wild-type controls