Phenotypes Associated with This Genotype

Genotype
MGI:2662520

• Allelic Composition: Mpl^tm1Mwm/Mpl^tm1Mwm
• Genetic Background: B6;129S2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent megakaryocytes ( J:83264 )

• mutant mice displayed a loss of megakaryocytes in the spleen and bone marrow

• however, there was no significant difference in the number of red blood cells, total white blood cells, neutrophils, bands, and esinophils in the peripheral blood

thrombocytopenia ( J:83264 )

• mice displayed an 85% decrease in platelet count

increased mean platelet volume ( J:83264 )

• mutant mice registered 6.25 um³ compared to control animals 4.7 um³

immune system

immune system phenotype ( J:83264 )

N • there was no significant alteration in the size and cellularity of the lymphoid organ

N • no alterations were detected in the ratios of B and T cells examined in the spleen, thymus and bone marrow