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Phenotypes Associated with This Genotype
Genotype
MGI:2662363
Allelic
Composition
Juntm1Wag/Juntm1Wag
Tg(Junb)1598Angl/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm1Wag mutation (0 available); any Jun mutation (12 available)
Tg(Junb)1598Angl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only a few mutant mice survive past weaning, with the oldest one reaching 7 months of age
• although Mendelian ratios are recovered at E14.5-E18.5, only some viable mutant mice are born
• only 4% of mutant mice reach weaning age

vision/eye
• newborn mutant mice have open eyes but do not show any other overt defects

cardiovascular system
N
• at E12.5, mutant fetuses exhibit normal formation of the aorta and pulmonary artery, indicating that development of the cardiac outflow tract is unaffected

liver/biliary system
N
• at E15.5, mutant fetuses display normal liver architecture

cellular
• similar to primary MEFs isolated from E12.5 Juntm1(Junb)Wag homozygotes, these mutant MEFs do not enter premature senescence and show increased proliferation relative to Juntm1Wag cells, but do not proliferate as fast as wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory