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Phenotypes Associated with This Genotype
Genotype
MGI:2662259
Allelic
Composition
Cd8atm1Mak/Cd8atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• lacks cytotoxic T cell response
• no response to class I MHC alloantigen but normal response to class II

immune system
• lacks cytotoxic T cell response
• no response to class I MHC alloantigen but normal response to class II
• inflammation is mostly resolved by 45 days after TMEV infection on the resistant C57BL/6 background
• infectious virus remains at 45 days, however, disease is absent by 10 months on the resistant C57BL/6 background

nervous system
• on the resistant C57BL/6 background, foci of demyelination at 45 days after TMEV infection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory