Phenotypes Associated with This Genotype

Genotype
MGI:2662016

• Allelic Composition: Cd38^tm1Lnd/Cd38^tm1Lnd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal humoral immune response ( J:49170 )

• in response to immunization with the TD antigen TNP(5)-KLH in alum adjuvant, mutants exhibit decreased hapten-specific IgM, IgG1, and IgE responses but mount normal hapten-specific IgG2a, IgG2b, IgG3 and IgA responses, however when mutants are immunized with TNP(5)-KLH in Freund's adjuvant, primary antibody responses are not different from wild-type

• mutants fail to mount significant secondary hapten-specific antibody responses

• mutants show elevated antibody responses to the TI-2 antigen alpha1-3 dextran but not to NP(27)-Ficoll

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:49170 )

• NAD+ glycohydrolase activity in the spleen is reduced to less than 1% of the activity seen in wild-type spleens and no activity is detected in the liver and brain