Phenotypes Associated with This Genotype

Genotype
MGI:2661102

• Allelic Composition: Ezh2^tm1Tara/Ezh2^tm1Tara; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-) and immature B cells (IgM+B220int), indicating impaired pro-B to pre-B cell transition

decreased immature B cell number ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of immature B cells (IgM+B220int)

abnormal immunoglobulin V(D)J recombination ( J:83216 )

• recombination of V_HJ558 segments is reduced to 25% of the control

abnormal pro-B cell morphology ( J:83216 )

• pro-B cells do not form a well-defined population of B220int, intracellular mu+ cells and the overall frequency of B220+, intracellular mu+ cells is reduced to 30%

decreased pre-B cell number ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-)

immune system

abnormal B cell differentiation ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-) and immature B cells (IgM+B220int), indicating impaired pro-B to pre-B cell transition

decreased immature B cell number ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of immature B cells (IgM+B220int)

abnormal immunoglobulin V(D)J recombination ( J:83216 )

• recombination of V_HJ558 segments is reduced to 25% of the control

abnormal pro-B cell morphology ( J:83216 )

• pro-B cells do not form a well-defined population of B220int, intracellular mu+ cells and the overall frequency of B220+, intracellular mu+ cells is reduced to 30%

decreased pre-B cell number ( J:83216 )

• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-)