Analysis Tools
reproductive system
| N |
• despite the male testicular hypoplasia, female ovarian mass is consistently normal
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• throughout life the testis weight is greatly reduced, and the highest mean testis weight of approximately 32 mg is found at 6 weeks of age
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• transplantation of C57BL/6J seminiferous tubules into the testes of homozygous mutants yields differentiation of type A spermatogonia into spermatids, but transplantation of seminiferous tubules from homozygous mutants into dominant spotting/viable dominant spotting compound heterozygotes, which lack germ cells, fail to produce mature spermatids indicating a defect in the intratubular environment
(J:1815)
• at 3 weeks of age histology shows occasional testicular tubules deficient in spermatogonial and primary spermatocytes, at 5 weeks of age some tubules hace predominantly Sertoli cells with a few spermatogonial cells and other tubules have maturing spermatids, at 6 to 7 weeks of age small numbers of sperm with normal morphology and good motility are found, but sperm are not found after 8 weeks of age and after 9 weeks of age the testis are devoid of spermatogenesis with small diameter tubules populated predominantly by Sertoli cells and type A spermatogonial cells
(J:9278)
• DNA synthesis in testes as assessed by tritiated thymidine uptake is readily detectable at 4.5 weeks of age, but only at low frequency at 7.5 weeks of age
(J:9278)
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endocrine/exocrine glands
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• throughout life the testis weight is greatly reduced, and the highest mean testis weight of approximately 32 mg is found at 6 weeks of age
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growth/size/body
| N |
• normal body weight at all ages from 3 weeks to a year
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nervous system
homeostasis/metabolism
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• although testosterone levels are within normal limits, serum follicle stimulating hormone levels in males are significantly higher than normal as early as 4 to 6 weeks of age and taper by 52 weeks of age
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