Phenotypes Associated with This Genotype

Genotype
MGI:2656909

• Allelic Composition: Erbb2^{tm3(Erbb2)Mul}/Erbb2^tm1Mll; Tg(ACTA1-cre)1Mll/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:82801 )

• when placed on a slippery surface, mutants are unable to position their limbs properly

• mutants exhibit spastic movements

abnormal reflex ( J:82801 )

• abnormal hindlimb extension reflexes

ataxia ( J:82801 )

muscle

abnormal muscle spindle morphology ( J:82801 )

• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired

absent muscle spindles ( J:82801 )

• absence of muscle spindles

nervous system

abnormal muscle spindle morphology ( J:82801 )

• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired

absent muscle spindles ( J:82801 )

• absence of muscle spindles

abnormal neuromuscular synapse morphology ( J:82801 )

• synapses at neuromuscular junctions contain reduced numbers of acetylcholine receptors

abnormal CNS synaptic transmission ( J:82801 )

• mutants exhibit reduced synaptic transmission at neuromuscular junctions; mepc amplitudes are reduced by about 15% compared to wild-type