Phenotypes Associated with This Genotype

Genotype
MGI:2655930

• Allelic Composition: Tg(Lck-Hhex)1Hro/0
• Genetic Background: C3HeB/FeJ-Tg(Lck-Hhex)1Hro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hyperplasia ( J:80777 )

abnormal double-negative T cell morphology ( J:80777 )

• 4.1-fold decrease in the relative percentage of CD25+CD44+ thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 3-fold increase of CD25-CD44- cells

increased CD8-positive, alpha-beta T cell number ( J:80777 )

• 3.7-fold increase in CD8+ thymocytes

decreased leukocyte cell number ( J:80777 )

• general leukopenia due to decreased T cells in the peripheral blood

decreased lymphocyte cell number ( J:80777 )

• decrease in absolute lymphocytes

decreased T cell number ( J:80777 )

• decrease in peripheral blood T cells, especially CD8+ cells

decreased double-positive T cell number ( J:80777 )

• 1.4-fold decrease in double positive thymocytes

immune system

thymus hyperplasia ( J:80777 )

abnormal double-negative T cell morphology ( J:80777 )

• 4.1-fold decrease in the relative percentage of CD25+CD44+ thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 3-fold increase of CD25-CD44- cells

increased CD8-positive, alpha-beta T cell number ( J:80777 )

• 3.7-fold increase in CD8+ thymocytes

decreased leukocyte cell number ( J:80777 )

• general leukopenia due to decreased T cells in the peripheral blood

decreased lymphocyte cell number ( J:80777 )

• decrease in absolute lymphocytes

decreased T cell number ( J:80777 )

• decrease in peripheral blood T cells, especially CD8+ cells

decreased double-positive T cell number ( J:80777 )

• 1.4-fold decrease in double positive thymocytes

endocrine/exocrine glands

thymus hyperplasia ( J:80777 )