Phenotypes Associated with This Genotype

Genotype
MGI:2655606

• Allelic Composition: Atf1^tm1Gsc/Atf1⁺; Creb1^tm2Gsc/Creb1^tm2Gsc
• Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:74982 )

• embryos die due to massive apoptosis

cellular

abnormal apoptosis ( J:74982 )

• apoptosis was detected in most cells present at E7.5

embryo

abnormal germ layer development ( J:74982 )

• at E7.5, embryos lack differentiated germ cell layers; at E9.5, some differentiated cells were seen, but no organized cell layers were apparent

delayed blastocyst hatching from the zona pellucida ( J:74982 )

• these embryos exhibited delayed hatching from the zona pellucida

absent egg cylinders ( J:74982 )

• an accumulation of cells at the distal end of conceptus was noted

abnormal blastocyst morphology ( J:74982 )

• preimplantation embryos had a morula appearance with no blastocoel or ICM seen

• however, the trophoblast forms normally

absent blastocoele ( J:74982 )

absent inner cell mass ( J:74982 )

absent allantois ( J:74982 )

absent amnion ( J:74982 )