Phenotypes for Cd4 Tg(Lck-icre)3779Nik MGI:2655529 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (2 available); any Cd4 mutation (85 available)
Cd4^tm1Nik mutation (2 available); any Cd4 mutation (85 available)
Tg(Lck-icre)3779Nik mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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