Phenotypes Associated with This Genotype

Genotype
MGI:2655528

• Allelic Composition: Cd4^tm1Litt/Cd4^tm1Nik; Tg(Lck-cre)3778Nik/0
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

abnormal interleukin-4 secretion ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation